- Sandwich Shop Restaurants, Sharpsburg
- School - Christian, Sharpsburg
- Screen Printing, Sharpsburg
- Secondary Schools, Sharpsburg
- Security Brokers & Dealers, Sharpsburg
- Security Services, Sharpsburg
- Shoe Dyers, Sharpsburg
- Shoe Repair Shops, Sharpsburg
- Shopping & Shopping Services, Sharpsburg
- Siding Contractors, Sharpsburg - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Signs, Sharpsburg
- Social Clubs & Organizations, Sharpsburg
- Social Services & Welfare, Sharpsburg
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- Specialty Animal Services, Sharpsburg
- Specialty Stores, Sharpsburg
- Sportswear Clothing Stores, Sharpsburg - Sports Clothes
- Stamp Collecting & Coin Dealers , Sharpsburg
- State Government, Sharpsburg
- Stocks & Bond Brokers, Sharpsburg
- Surveyor Services, Sharpsburg - Surveying Service
- Swimming Pool Covers & Enclosures, Sharpsburg
- Swimming Pool Designing & Consulting, Sharpsburg
- Swimming Pool, Sauna & Spa Contractors, Sharpsburg
- Swimming Pools Contractors, Sharpsburg - Install Inground - Above Ground Pools
- Swimming Pools Repair, Service, Supplies, Sale & Installation, Sharpsburg
- Swimming Pools Supplies, Equipment & Accessories, Sharpsburg
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