- Sales & Marketing Consultant, Clarkston
- Sandwich Shop Restaurants, Clarkston
- Schools For The Deaf, Clarkston
- Screen Printing, Clarkston
- Secretarial & Court Reporting Services, Clarkston
- Security & Surveillance System & Equipment, Clarkston
- Security Alarm Systems - Home & Business, Clarkston
- Security Control Systems & Monitoring, Clarkston - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Guard & Patrol Service, Clarkston - Bodyguard, Guard Dogs, Etc
- Security Services, Clarkston
- Sewer & Drain Cleaning & Repair, Clarkston - Drain Cleaner & Installation Services
- Sheet Metal Contractors, Clarkston - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Clarkston
- Shopping & Shopping Services, Clarkston
- Small Business Services, Clarkston
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- Social Services & Welfare, Clarkston
- Societies & Foundation Associations, Clarkston
- Soul Food Restaurants, Clarkston
- Special Education & Care, Clarkston
- Special Needs Transportation, Clarkston
- Specialty Animal Services, Clarkston
- Specialty Stores, Clarkston
- Sporting Goods Stores, Clarkston
- Staffing & Support Services, Clarkston
- State Government, Clarkston
- Structural Engineer, Clarkston
- Student Housing & Services, Clarkston
- Support Services, Clarkston
- Surveyor Services, Clarkston - Surveying Service
- Swimming Pools, Clarkston
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