- Sand Gravel & Aggregate, Claxton
- Sandblasting, Claxton - General Contractors
- Sandwich Shop Restaurants, Claxton
- Seafood Restaurants, Claxton
- Secondary Schools, Claxton
- Shopping & Shopping Services, Claxton
- Signs, Claxton
- Skin Care & Cosmetology Salons, Claxton
- Skin Care Products & Treatments, Claxton
- Social Security And Disability Attorneys & Lawyers, Claxton
- Social Security And Disability Lawyers & Attorneys, Claxton
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- Social Services & Welfare, Claxton
- Special Interest Schools Or Instruction, Claxton
- Specialty Stores, Claxton
- State Government, Claxton
- Steak House Restaurants, Claxton
- Steel & Metal Goods, Claxton - Steel Distributors
- Steel Erection Contractors, Claxton - Steel Erectors
- Steel Manufacturers, Claxton
- Substance Abuse Clinics, Claxton - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Swimming Pool, Sauna & Spa Contractors, Claxton
- Swimming Pools Contractors, Claxton - Install Inground - Above Ground Pools
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