- Sandwich Shop Restaurants, Clayton
- Secondary Schools, Clayton
- Security Alarm Systems - Home & Business, Clayton
- Security Brokers & Dealers, Clayton
- Security Guard & Patrol Service, Clayton - Bodyguard, Guard Dogs, Etc
- Security Services, Clayton
- Shoe Store - More, Clayton
- Shopping & Shopping Services, Clayton
- Social Services & Welfare, Clayton
- Societies & Foundation Associations, Clayton
- Specialty Animal Services, Clayton
- Specialty Communication Companies & Services, Clayton
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- Specialty Stores, Clayton
- Speech & Hearing Specialists, Clayton
- Speech Pathologists, Clayton - Speech & Language Therapy
- Steak House Restaurants, Clayton
- Steel Manufacturers, Clayton
- Stock & Bond Brokers & Dealers, Clayton
- Stocks & Bond Brokers, Clayton
- Stone, Clayton
- Stoves & Furnace Equipment, Clayton - Fittings & Repair Parts
- Substance Abuse Clinics, Clayton - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Support Services, Clayton
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