- Sandwich Shop Restaurants, Pooler
- Satellite TV Service, Pooler
- Savings Banks, Pooler
- Scottish Restaurants, Pooler
- Screen Houses, Pooler
- Seafood Restaurants, Pooler
- Secondary Schools, Pooler
- Security & Commodity Brokers, Pooler
- Security Brokers & Dealers, Pooler
- Senior Citizens Information & Services, Pooler
- Senior Citizens Service & Health Organizations, Pooler
- Septic Tank Pumping & Cleaning, Pooler - Septic Systems
- Sherwin Williams Paint, Pooler
- Shipping Companies, Pooler
- Shoe Stores, Pooler - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Pooler
- Skating Rink & Hockey Operation Services, Pooler
- Skin Care & Cosmetology Salons, Pooler
- Sleep Disorders Treatment & Information Centers, Pooler
- Snacks & Desserts, Pooler
- Social & Human Services Autism Services, Pooler
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- Social Services & Welfare, Pooler
- Southern Style Restaurants, Pooler
- Special Education & Care, Pooler
- Special Interest Schools Or Instruction, Pooler
- Special Needs Transportation, Pooler
- Specialty Animal Services, Pooler
- Specialty Stores, Pooler
- Speech & Hearing Specialists, Pooler
- Speech Pathologists, Pooler - Speech & Language Therapy
- Sporting Goods Stores, Pooler
- Staffing & Support Services, Pooler
- Stamp Collecting & Coin Dealers , Pooler
- State Government, Pooler
- Steak House Restaurants, Pooler
- Steel Erection Contractors, Pooler - Steel Erectors
- Stocks & Bond Brokers, Pooler
- Structural Steel Erection, Pooler
- Stucco Siding Contractors, Pooler - Stucco Repair & Installation
- Stucco Siding, Granite & Grouting Contractors, Pooler
- Submarine Sandwich Restaurants, Pooler
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